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Medical Diagnostic Laboratories Publications

Stemmer, S and Shurshalina, A. Colonoscopic tattoo dye spillage mimics endometriosis on laparoscopy. J Minim Invasive Gynecol, 2014 Jul-Aug; 21(4):704-7. PMID: 24473152.

Walsh, P., Overmyer, C., Hancock, C., Heffner, J., Walker, N., Nguyen, T., Shanholtzer, L., Caldera, E., Pusavat, J., Mordechai, E., Adelson, M.E. & Iacono, K.T. 2013. Is the interpretation of rapid antigen testing for respiratory syncytial virus as simple as positive or negative? Emerg Med J 31, 153-159. PMID: 23964062

Walsh, P., Overmyer, C., Hancock, C., Heffner, J., Walker, N., Nguyen, T., Shanholtzer, L., Pusavat, J., Mordechai, E., Adelson, M.E. & Iacono, K.T. 2013. Authors' response. Emerg Med J 31, 174. PMID: 24136121

Antimicrobial Resistance Division

Vermitsky, J-P., Chadwick, S.G., Self, M.J., Mordechai, E., Adelson, M.E., Nickels, J.T. Jr., and Gygax, S.E. 2009. CgUpc2 is the master regulator of ergosterol biosynthetic genes in Candida glabrata. Antimicrob. Agents Chemother. Manuscript in preparation.

Vermitsky, J.-P., Self, M.J., Chadwick, S.G., Katiyar, S.K., Mordechai, E., Adelson, M.E., Edlind, T.D., and Gygax, S.E. 2009. cAMP-PKA kinase Tpk3 negatively regulates Candida glabrata Pdr1. Antimicrob. Agents Chemother. Manuscript in preparation.

Prasad, A., Mordechai, E., Adelson, M.E., and Gygax, S.E. 2009. PBP4 Polymorphisms Generate Penicillin Tolerance in Group B Streptococcus. Nature Medicine. Manuscript in preparation.

Gygax SE, Vermitsky JP, Self MJ, Mordechai E, Adelson ME, Trama JP. 2008. Antifungal resistance in vaginal Candida clinical isolates. Antimicrob Agents Chemother, manuscript under review. PMID: 18591262

Gygax, S.E., Vermitsky, J.-P., Self, M.J., Chadwick, S.G., Mordechai, E., Adelson, M.E., and Trama, J.P. 2008. Antifungal Resistance of Candida glabrata Vaginal Isolates and the Development of a qRT-PCR-based Azole Susceptibility Assay. Antimicrob. Agents Chemother. 52(9): 3424-3426. PMID: 18591262

Vermitsky JP, Self MJ, Chadwick SG, Trama JP, Mordechai E, Adelson ME. 2007. A survey of vaginal flora Candida species isolates from women of different age groups by use of species-specific PCR detection. J Clin Microbiol, 46(4):1501-1503. PMID: 18305136

Gygax SE, Schuyler JA, Trama JP, Mordechai E, Adelson ME. 2007. The detection of erythromycin and clindamycin resistance genes in both Group B Streptococcal clinical isolates and cervicovaginal/rectal swabs. Microb Drug Resist, 13(2):119-123. PMID: 17650964

Gygax SE, Schuyler JA, Kimmel LE, Trama JP, Mordechai E, Adelson, ME. 2006. Erythromycin and clindamycin resistance in Group B Streptococcal clinical isolates. Antimicrob Agents Chemother, 50(5):1875-7. PMID: 16641466

Tumor Cell Biology Division

Hilbert D, Paulish T, Mordechai E, Adelson ME, Gygax SE, and Trama JP. 2009. Antimicrobial non-susceptibility of cervico-vaginal and rectal Escherichia coli isolates is associated with phylogeny and plasmid carriage. Eur J Clin Microb Infect Dis. 28(11): 1399-403. PMID: 19639348

Hilbert DW, Paulish TE, Mordechai E, Adelson ME, and Trama JP. 2008. O serogroups, phylogeny, and virulence factors of cervicovaginal and rectal Escherichia coli isolates. Eur J Clin Microb Infect Dis. 27(12): 1265-8. PMID: 18584221

Libby EK, Pascal KE, Mordechai E, Adelson ME, Trama JP. 2008. Atopobium vaginae triggers an innate immune response in an in vitro model of bacterial vaginosis. Microb Infect, 10(4):439-446. PMID: 18403235

Hilbert DW, Pascal KE, Libby EK, Mordechai E, Adelson ME, Trama JP. 2008. Uropathogenic Escherichia coli dominantly suppresses the innate immune response of bladder epithelial cells by a lipopolysaccharide- and Toll-like receptor 4-independent pathway. Microb Infect, 10(2):114-21. PMID: 18248759

Trama JP, Pascal KE, Zimmerman JA, Self MJ, Mordechai E, Adelson ME. 2008. Rapid detection of Atopobium vaginae and association with organisms implicated in bacterial vaginosis. Mol Cell Probes, 22(2):96-102. PMID: 17913456

Trama JP, Pascal KE, Zimmerman JA, Self MJ, Mordechai E, Adelson ME. 2007. Identification and genotyping of Molluscum Contagiosum virus from genital swab samples by Real-Time PCR and Pyrosequencing. J Clin Virol, 40(4):325-329. PMID: 17997134

Trama JP, Adelson ME, Raphaelli I, Mordechai E. 2005. Detection of Candida species in vaginal samples in a clinical laboratory setting. Infect Dis Obstet Gynecol, 13(2):63-7. PMID: 16011995

Trama JP, Mordechai E, Adelson ME. 2005. Detection and identification of Candida species associated with candida vaginitis by Real- Time PCR and Pyrosequencing. Mol Cell Probes, 19(2):145-52. PMID: 15680216

Trama JP, Mordechai E, Adelson ME. 2005. Detection of Aspergillus fumigatus and a mutation that confers reduced susceptibility to itraconazole and posaconazole by Real-Time PCR and Pyrosequencing. J Clin Microbiol. 43(2):906-8. PMID: 15695702

Molecular Diagnostics Development Division

Biggs C, Walsh P, Overmyer CL, Gonzalez D, Feola M, Mordechai E, Adelson ME, and Iacono KT. 2010. Performance of influenza rapid antigen testing in influenza in emergency department patients. Emerg Med J. 27(1): 5-7. PMID: 20028996

McCool TL, Hoey JG, Montileone F, Goldenberg HB, Mordechai E, Adelson ME. 2008. Discovery and analysis of Bartonella henselae antigens for use in clinical serological assays. Diagn Microbiol Infect Dis, 60(1):17-23. PMID: 17889484

Loa CC, Mordechai E, Tilton RC, Adelson ME. 2006. Production of recombinant Bartonella henselae 17 kDa protein for antibody-capture enzyme-linked immunosorbent assay. Diagn Microbiol Infect Dis, 55(1):1-7. PMID: 16490335

Meer-Scherrer L, Adelson ME, Mordechai E, Tilton RC. 2006. Neuroborreliosis associated with Alzheimer’s disease. Curr Microbiol, 52(4):330-2.

Drisko J, Bischoff B, Giles C, Adelson ME, Rao RV, McCallum R. 2005. Evaluation of 5 probiotic products for bacteria by DNA extraction and PCR analysis. Dig Dis Sci, 50(6):1113-7.

Adelson ME, Feola M, Trama JP, Tilton RC, Mordechai E. 2005. Simultaneous detection of herpes simplex virus types 1 and 2 by Real-Time PCR and Pyrosequencing. J Clin Virol, 33(1):25-34. PMID: 15797362

Adelson ME, Rao RV, Tilton RC, Cabets K, Eskow E, Fein L, Occi JL, Mordechai E. 2004. Prevalence of Borrelia burgdorferi, Bartonella species, Babesia microti, and Anaplasma phagocytophila in Ixodes scapularis collected in northern New Jersey. J Clin Microbiol, 42:2799-2801. PMID: 15184475

Meer-Scherrer L, Adelson ME, Mordechai E, Lottaz B, Tilton RC. 2004. Babesia microti infection in Europe. Curr Microbiol, 48(6):435-7. PMID: 15170239

Mogilyansky E, Loa CC, Adelson ME, Mordechai E, Tilton RC. 2004. Comparison of western immunoblots and the C6 Lyme antibody test for the laboratory detection of Lyme disease. Clin Diagn Lab Immunol, 11(5):924-929. PMID: 15358654

Loa CC, Adelson ME, Mordechai E, Raphaelli I, Tilton RC. 2004. Serological diagnosis of human babesiosis by IgG enzyme-linked immunoabsorbent assay. Curr Microbiol, 49:385-389. PMID: 15696612

Eskow E, Adelson ME, Rao RV, Mordechai E. 2003. Evidence for disseminated Mycoplasma fermentans in New Jersey residents with antecedent tick attachment and subsequent musculoskeletal symptoms. J Clin Rheumatol, 9:77-87. PMID: 17041434

Tilton RC. 2003. New tests for Lyme disease. Clin Microbiol Newsl, 25(19):145-149.

Eskow E, Rao RV, Mordechai E. 2001. Concurrent infection of the central nervous system by Borrelia burgdorferi and Bartonella henselae: Evidence for a novel tick-borne disease complex. Arch Neurol, 58:1357-1363. PMID: 11559306

Hoey JG, Valois-Cruz F, Goldenberg H, Voskoboynik Y, Pfiffner J, Mordechai E, and Adelson ME. Development of an IgM capture-based ELISA for detection of acute infection with Bartonella henselae. Clin Vac Immun, 16(2): 282-284. PMID: 19052161

Pharmacogenomics Division

Morgan J, McCourt P, Rankin L, Swain E, Rice LM, and Nickels Jr. JT. 2009. Altering sphingolipid metabolism in yeast cells lacking the amphiphysin ortholog, Rvs161, re-initiates sugar transporter endocytosis. Eukaryot Cell, 8(5): 779-789. PMID: 19286982

McCourt P, Morgan J, Nickels Jr. JT. 2009. Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphipysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis. J Biol Chem, 284(18): 11930-11941.

McCourt P, Morgan J, Nickels Jr JT. 2009. Stress-induced ceramide-activated protein phosphatase can compensate for loss of amphiphysin-like activity in Saccharomyces cerevisiae and functions to reinitiate endocytosis. J Biol Chem. In press.

Oncoveda Publications

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, J. T. Nickels, Jr., and L. M. Rice. 2015. Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin. Tumour Biol 36:6067-6074. PMID: 25736928

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, M. Pusey, J. T. Nickels, Jr., and L. M. Rice. 2015. Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells. Tumour Biol 36:6383-6390.PMID: 25833693

Wandzioch, E., Pusey, M., Werda A., Bhaskar, A., & Rice, L.M. 2014. High expression of PME-1 in endometrial cancer cells promotes epithelial to mesenchymal transition via enhanced ERK, Akt, and β-catenin phosphorylation. Cancer Research. 2014 Aug 15; 74(16):4295-305. PMID: 24928782

Pusey, M., Bail, S., Werda, A., Rice, L.M. 2014. Protein Phosphatase Methylesterase 1: A potential therapeutic target and companion diagnostic marker for cancer. Cancer Cell & Microenvironment. 20141(5): e299.

Hilbert, D.W., Paulish-Miller, T.E., Tan, C.K., Carey, A.J., Ulett, G.C., Mordechai, E., Adelson, M.E., Gygax, S.E. & Trama, J.P. 2012. Clinical Escherichia coli isolates utilize alpha-hemolysin to inhibit in vitro epithelial cytokine production. Microbes Infect 14, 628-638. PMID: 22326301

Stemmer, S.M., Adelson, M.E., Trama, J.P., Dorak, M.T. & Mordechai, E. 2012. Detection rates of trichomonas vaginalis, in different age groups, using real-time polymerase chain reaction. J Low Genit Tract Dis 16, 352-357. PMID: 22968052

Scher, M.B., Elbaum, M.B., Mogilevkin, Y., Hilbert, D.W., Mydlo, J.H., Sidi, A.A., Adelson, M.E., Mordechai, E. & Trama, J.P. 2012. Detecting DNA methylation of the BCL2, CDKN2A and NID2 genes in urine using a nested methylation specific polymerase chain reaction assay to predict bladder cancer. J Urol 188, 2101-2107. PMID: 23083854

Pallai, R., Bhaskar, A., Sodi, V. & Rice, L.M. 2012. Ets1 and Elk1 transcription factors regulate cancerous inhibitor of protein phosphatase 2A expression in cervical and endometrial carcinoma cells. Transcription 3, 323-335. PMID: 23117818

Huang, L.P., Savoly, D., Sidi, A.A., Adelson, M.E., Mordechai, E. & Trama, J.P. 2012. CIP2A protein expression in high-grade, high-stage bladder cancer. Cancer Med 1, 76-81. PMID: 23342256

Datta A, Adelson ME, Mogilevkin Y, Mordechai E, Sidi AA, Trama JP. Oncoprotein DEK as a tissue and urinary biomarker for bladder cancer. BMC Cancer. 2011 Jun 10; 11: 234. PMID: 21663673

Nolt JK*, Rice LM*, Gallo-Ebert C, Bisher ME, Nickels JT. PP2ACdc55 is required for multiple events during meiosis I. Cell Cycle. 2011 May 1; 10(9): 1420 – 34. (* These authors contributed equally.) PMID: 21455032

Huang LP, Adelson ME, Mordechai E, Trama JP. CIP2A expression is elevated in cervical cancer. Cancer Biomark. 2010 – 2011; 8(6): 309 – 17. PMID: 22072119

Martin AG, Trama J, Crighton D, Ryan KM, Fearnhead HO. Activation of p73 and induction of Noxa by DNA damage requires NK-kappa B. Aging (Albany NY). 2009 Feb 18; 1(3):335-49. PMID: 20195489

Huang LP, Lyu SC, Clayberger C, Krensky AM. Granulysin-mediated tumor rejection in transgenic mice. J Immunol. 2007 Jan 1; 178(1):77-84. PMID: 17182542

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Venenum Biodesign Publications

Stroke, Ilana L.; Sturzenbecker, Laurie J.; Letourneau, Jeffrey J.; Quintero, Jorge G.; Sabalski, Joan E.; Marinelli, Brett; Pechik, Igor; Diller, David; Paulish-Miller, Teresa; Hilbert, David W.; Gygax, Scott; Stein, Philip; Webb, Maria. High throughput screening of combinatorial libraries for inhibitors of Clostridium difficile toxins. Society for Laboratory Automation and Screening 2nd Annual Conference and Exhibition (Orlando, Florida) 12-16 January, 2013.

Webb, M. The Pivitol Role of Vertical Integration in Biotechnology. Rutgers University, November 5, 2012.

Waxman EA, McQueney MS. Systematic Analysis of the Contribution of the Modifier Subunit of \gamma-Glutamylcysteine Ligase Towards Glutathione Production and Cell Survival. Society for Neuroscience, New Orleans, LA, October 13-17, 2012.

McQueney MS, Uveges A, Malone J, O'Brien L, Cole A, Webb M. An Ultra High Throughput Screen of the Venenum Discovery Library for PARP-1 Inhibitors. Inflammation Research Association, Bolton Landing, NY, September 9-13, 2012.

Webb, M. How to Mine Novel Biology Space with Technology Picks and Shovels. Kean University, March 12, 2012.

Stroke IL, Hilbert DW, Letourneau JJ, Paulish-Miller T, Quintero JG, Sabalski JE. Identification and Characterization of Small Molecules Targeting Clostridium difficile. Society for Laboratory Automation and Screening, San Diego, CA, February 6-8, 2012.

Beasley JR, Malone J, O'Brien L, Huang C, Sieber-McMaster E, Shi D, Xu X, Nawoschik S, Pham Q, Webb M. Discovery of GPBAR1 (TGR5) Agonists from a 1536-well UHTS of the ECLiPS Compound Collection. TGR5: Society for Laboratory Automation and Screening, San Diego, CA, February 6-8, 2012.

Huang C, Zhao J, Simhadri S, Webb M, Ohlmeyer M, Zhi L. Discovery of a Novel Series of mGluR5 Antagonists. Gordon Research Conference, Medicinal Chemistry, Colby- Sawyer College, New London, NH, August 7-12, 2011.

Swanson RN, Stroke IL, Manners MT, Gallo-Ebert C, Nickels J. Engineering Transcription Factors for Use in Ultra-High Throughput DNA Binding Assays. 7th Annual Protein Engineering Summit, Boston, MA. May 9-13, 2011.

Stroke IL, Manners MT, Swanson RN, Dimitrov D, Gallo-Ebert C, Nickels J. Targeting the Transcription Factor Upc2 for Antifungal Drug Discovery. Society for Biomolecular Sciences Annual Meeting, Orlando, Fla., March 26-31, 2011.

Kruijf PD, Lim HD, Roumen L, Renjaan VA, Zhao J, Webb ML, Auld DS, Wijkmans JCHM, Zaman GJR, Smit MJ, Graaf CD, Leurs R. Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor. Molecular Pharmacology, 80:1108-1118, 2011.

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Institute of Metabolic Disorders Publications

Villasmil, M. L., J. Francisco, C. Gallo-Ebert, M. Donigan, H. Y. Liu, M. Brower, and J. T. Nickels, Jr. 2016. Ceramide signals for initiation of yeast mating-specific cell cycle arrest. Cell Cycle 15:441-454.PMID: 26726837

Joseph, B. K., H. Y. Liu, J. Francisco, D. Pandya, M. Donigan, C. Gallo-Ebert, C. Giordano, A. Bata, and J. T. Nickels, Jr. 2015. Inhibition of AMP Kinase by the Protein Phosphatase 2A Heterotrimer, PP2APpp2r2d. J Biol Chem 290:10588-10598.PMID: 25694423

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, J. T. Nickels, Jr., and L. M. Rice. 2015. Cancerous inhibitor of protein phosphatase 2A promotes premature chromosome segregation and aneuploidy in prostate cancer cells through association with shugoshin. Tumour Biol 36:6067-6074.PMID: 25736928

Pallai, R., A. Bhaskar, N. Barnett-Bernodat, C. Gallo-Ebert, M. Pusey, J. T. Nickels, Jr., and L. M. Rice. 2015. Leucine-rich repeat-containing protein 59 mediates nuclear import of cancerous inhibitor of PP2A in prostate cancer cells. Tumour Biol 36:6383-6390.PMID: 25833693

Rice, L.M., Donigan, M., Yang, M., Liu, W., Pandya, D., Joseph, B.K., Sodi, V., Gearhart, T.L., Yip, S.C., Bouchard, M., & Nickels, J.T. Jr. Protein phosphatase 2A regulates low-density lipoprotein uptake through regulating SREBP-2 DNA binding. Journal of Biological Chemistry, 2014 Jun 13; 289(24):17268-17279. PMID: 24770487

Gallo-Ebert, C., Donigan, M., Stroke, I.L., Swanson, R.N., Manners, M.T., Francisco, J., Toner, G., Gallagher, D., Huang, C.Y., Gygax, S.E., Webb, M. & Nickels, J.T., Jr. 2014. Novel antifungal drug discovery based on targeting pathways regulating the fungus-conserved Upc2 transcription factor. Antimicrob Agents Chemother 58, 258-266.

McCourt, P., Gallo-Ebert, C., Gonghong, Y., Jiang, Y. & Nickels, J.T., Jr. 2013. PP2A(Cdc55) regulates G1 cyclin stability. Cell Cycle 12, 1201-1210.

Gallo-Ebert, C., Donigan, M., Liu, H.Y., Pascual, F., Manners, M., Pandya, D., Swanson, R., Gallagher, D., Chen, W., Carman, G.M. & Nickels, J.T., Jr. 2013. The yeast anaerobic response element AR1b regulates aerobic antifungal drug-dependent sterol gene expression. J Biol Chem 288, 35466-35477.

Yang, M., Liu, W., Pellicane, C., Sahyoun, C., Joseph, B.K., Gallo-Ebert, C., Donigan, M., Pandya, D., Giordano, C., Bata, A. & Nickels, J.T., Jr. 2013. Identification of miR-185 as a regulator of de novo cholesterol biosynthesis and low density lipoprotein uptake. J Lipid Res 55, 226-238.

Gallo-Ebert, C., McCourt, P.C., Donigan, M., Villasmil, M.L., Chen, W., Pandya, D., Franco, J., Romano, D., Chadwick, S.G., Gygax, S.E. & Nickels, J.T., Jr. 2012. Arv1 lipid transporter function is conserved between pathogenic and nonpathogenic fungi. Fungal Genet Biol 49, 101-113.

PharmOptima Publications

Ramos DM, d'Ydewalle C, Gabbeta V, Dakka A, Klein SK, Norris DA, Matson J, Taylor SJ, Zaworski PG, Prior TW, Snyder PJ, Valdivia D, Hatem CL, Waters I, Gupte N, Swoboda KJ, Rigo F, Bennett CF, Naryshkin N, Paushkin S, Crawford TO, Sumner CJ. 2019. Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment. Clin Invest https://doi.org/10.1172/JCI124120. [Epub ahead of print].